Rush sued the company in 2005 after taking Prempro for nine years and developing breast cancer in 1999. There is a gag order in place in Rush's case.
In a pretrial filing in the Rush case, Wyeth attorneys pointed out that one episode of ABC's "Grey's Anatomy" featured a plot line that involved a man who was taking estrogen while undergoing a sex change. The male character in the show learned he had developed breast cancer and was told that continuing estrogen therapy in order to remain a woman came at the cost of dying of breast cancer.