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It has been known for decades that generic ibuprofen can cause Stevens-Johnson Syndrome (SJS) and its deadlier form known as Toxic Epidermal Necrolysis (TEN). These extremely rare life-threatening conditions can cause the top layer of skin to detach, resulting in massive skin loss. They especially affect mucous membranes such as the mouth, eyes and female genitalia.
Read more here: http://www.courthousenews.com/2012/01/18/43145.htm