I found this report after hearing more about the recent black box warning issued by the FDA regarding Promethazine:
"The first reported cases of intra-arterial promethazine (Phenergan) injection causing complications were in the late 1960s." There have been literature reports of adverse outcomes after accidental intra-arterial injections of drugs since the 1940s.
The study presented two cases of intra-arterial promethazine injection that led to digital necrosis. Both cases eventually led to amputations.
The study may be found here.
