Tuesday, February 13, 2007

Zyprexa: Study Finds Reason for Weight Gain

One of the side effects of the drug Zyprexa (which was prescribed to treat mental illnesses such as schizophrenia) was that it resulted in substantial weight gain in patients taking the medication.

According to a recent report, the drug increases the activity of an enzyme called AMPK in cells in the part of the brain that regulates eating behavior. AMPK is shorthand for the AMP-activated protein kinase (AMPK). The cells that make up our bodies need a constant supply of energy to function. AMPK is key in regulating cellular energy, and serves as a gas gauge by sensing how much energy a cell has.

The study was published in the Proceedings of the National Academy of Sciences.

AMPK's increase was because the antipsychotic drugs were interfering with the important protein histamine.

For more, go here.