This is from several sources, including legal professionals who attended the Humeston trial in person:
At the Humeston trial, more powerful testimony that can't bode well for Merck: A day's use of the painkiller could be enough to cause a heart attack, Dr. Luchessi testified Monday.
Vioxx breaks takes nearly four days (he said on the stand 85 hours) to leave the blood system, according to Dr. Lucchesi. He also said that based on the information at the time of its release, there was reason to believe that a single dose OR multiple doses , could lead to an adverse event such as an MI or stroke.